AfpTest (for ONTDs): Detection Rate (for anencephaly): 98%. Detection Rate (for spina bifida): 90%

Afp Test (for ONTDs)

Maternal serum alpha-fetoprotein (AFP) screening was originally designed to identify a fetus' risk for open neural tube defects (ONTDs). It is generally offered to all pregnant women regardless of their medical background and family history. It may be used to predict, but with less specificity, increased risk for other adverse pregnancy outcomes. Some other conditions known to be associated with increased maternal serum AFP are:

  • Multiple gestations
  • Incorrect gestational dating
  • Miscarriage risk
  • Stillbirth
  • Intrauterine growth retardation (IUGR)
  • Premature labor
  • Premature delivery
  • Oligohydraminos
  • Preeclampsia
  • Abruptio placentae
  • Triploidy
  • Fetal complications

The etiology of increased maternal serum AFP in pregnancies destined to manifest these conditions is undefined. Lab reports to physicians include patient-specific risks for open spina bifida (at a 90% detection rate) and anencephaly (at a 98% detection rate).

(References 31)


DISCLAIMER: Pursuant to applicable federal and/or state laboratory requirements, Eurofins NTD, LLC has established and verified the accuracy and precision of its testing services. Tests are developed and performance characteristics determined by Eurofins NTD, LLC. The methods and performance characteristics have been reviewed and approved by the New York State Department of Health.

DISCLAIMER: This test is a part of a lab service offering provided by Eurofins NTD, LLC. The test was developed and its performance characteristics determined by Eurofins NTD, LLC. It has not been cleared or approved by the U.S. Food and Drug Administration. The methods and performance characteristics have been reviewed and approved by the New York State Department of Health. The test results do not eliminate the possibility that this pregnancy may be associated with birth defects including open neural tube defects, ventral wall defects, Down Syndrome, trisomy 18, or other disorders not detectable by this screening test.